Adverse Events

If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in the package leaflet. You can also report side effects directly via the Yellow Card Scheme at By reporting side effects you can help provide more information on the safety of this medicine.

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Patients and Carers
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Epistatus 10mg in 1mL oromucosal solution midazolam (as maleate) brand logo
Patient and Carers    -    Epistatus    -    Instructions to administer Epistatus


Instructions to administer Epistatus

If you have any questions, or would like any information that is not provided on this website, please talk to your doctor or healthcare professional.

Instructions to administer Epistatus

Epistatus is for oromucosal (“buccal”) use only, and must only be used in the mouth. It should be administered directly from the pre-filled buccal syringe into the patient’s buccal cavity (the space between the inner cheek and the gums):

Epistatus 10mg in 1mL oromucosal solution midazolam (as maleate) image of closed syringe case

Pull the tamper evident tab on the side of the plastic packaging case, open it and take the syringe out.

Epistatus pre-filled syringe in open case

Do not use if the solution is not clear (e.g. if it’s cloudy or white particles are present)

Epistatus pre-filled syringe with amber sheath cap partially removed

Holding the clear finger grips, unscrew the amber sheath cap in an anti-clockwise direction.

Epistatus pre-filled syringe with amber sheath cap entirely removed

Remove the amber sheath cap and dispose of it safely.

Carer's hand gently pinchng patient's cheek to allow space for syringe

Using your finger and thumb, gently pinch and pull back the patient’s cheek. Place the tip of the syringe into the back of the space between the inside cheek and the lower gum (buccal cavity).

Carer's hand slowly administering half of solution into patient's available buccal cavity

Slowly administer approximately half of the solution to the buccal cavity on one side of the mouth, and then administer the remainder slowly to the other side, by pressing the syringe plunger until it stops. If it is particularly difficult to get the syringe into one buccal cavity, then administer the whole dose over a duration of 4-5 seconds into the other buccal cavity.

Patient's face highlighting target area where Epistatus was administered

Any unused product or waste material should be disposed of safely.

Epistatus demonstration video

Everyone who might need to administer this medication should receive training; usually this is provided by your healthcare professional. The following video may be helpful as a training aid:

“How to administer Epistatus” leaflet for patients and carers

There is also a leaflet with written instructions; this can be accessed and printed by clicking here.

Epistatus 10mg in 1mL oromucosal solution midazolam (as maleate) brand logo
10mg in 1mL Oromucosal Solution
Midazolam (as maleate)
Veriton Pharma brand logo

© 2017 Veriton Pharma Ltd. All Rights Reserved. Please read the Legal Notice for further details. Company Registration No. 03305136.

This website is produced and maintained by Veriton Pharma Ltd, the company that developed and sells Epistatus.

This information is provided as a resource for patients who have been prescribed Epistatus by their doctor or other healthcare professional, and for their carers or family members who may be required to administer it.

Item code number EDM-1022-2019. Date of preparation: March 2019.

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